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Research of functional food/functional material

  • 「Composition having lipolysis promoting action」Patent overview

    The "composition having a lipolysis-promoting action" of the present invention is one having an excellent lipolysis and blood pressure lowering action due to a synergistic action with "salmon milt extract/beer yeast extract/young barley leaf extract/chicken collagen". is.

  • 「Lipolysis promoting action」

    The experiment involves (i) culturing fat precursor cells in mice, adding a fat cell differentiation-inducing agent to induce differentiation to fat cells, (ii) further culturing the cells in an insulin-containing medium, and then, it added “Salmon white fruit extract, beer yeast extract, barley young leaf extract, chicken collagen”. (iii) The fat decomposition effect was measured from the amount of glycerol because the fat decomposes to produce glycerol. The barley young leaf extract had a lipolytic action separately, but the mixture added with each component has a lipolytic action superior to the state of the barley young leaf extract.

  • 「ACE inhibitory activity」

    As an experiment of the hypotensive action, a substance obtained by adding a digestive enzyme (Pepsin trypsin) to each component and mixture and then freeze-drying the deactivated processing liquid is used to measure the absorbance value. It has been found that the cause of elevated blood pressure is angiotensin I's ACE-converting enzyme, which results in angiotensin II, which is caused by the constriction of blood vessels that angiotensin II has. On the other hand, the enzyme-treated mixture showed good ACE inhibitory activity and expected blood pressure drop.

  • 「Adiponectin production accelerating composition」Patent overview

    As the main component of salmon milt extract, the invented adiponectin production accelerating composition has beer yeast extract, chicken collagen and mineral-containing yeast and excellent adiponectin production accelerating effect by mixing them.

    ◎Adiponectin is physiological active substance (cytokine) secreted from fat cells and one of good substance. It repairs damaged blood vessels (standard value 5~10㎍/ml) occurring in considerable quantity in the blood and prevents and improves arteriosclerosis. And insulin will work better so that it will be useful for prevention and improvement of diabetes. The more visceral fat increases, secretion of Adiponectin decreases, blood concentration is reduced.Because adiponectin itself can’t be ingested directly, it is important to ingest nutrients promoting adiponectin secretion.

  • 「Adiponectin production accelerating effect」

    “Example”
    We cultivated mouse fibroblast cell, induced and guided fat cells, then enlarged fat cells. After cultivated this cell in insulin-containing medium24hours and decreased insulin secretion, we added composition of “salmon milt extract/ beer yeast extract/ chicken collagen and mineral-containing
    yeast” as 50㎍/ml and 250㎍/ml. Then we found the result that adiponectin concentration was increased compared with additive‐free (control)condition, after culturing 48 hours at 37℃.


Adiponectin production accelerating composition Patent overview

  • Patent acquisition country

    Japan

    Patent acquisition date

    May 27, 2011

    Patent No
    4750213

  • Patent acquisition country

    The United States of America

    Patent acquisition date

    November 11, 2014

    Patent No
    US8883138B2

  • Patent acquisition country

    People’s Republic of China

    Patent acquisition date

    December 3, 2014

    Patent No
    ZL201180024775.7

  • Patent acquisition country

    Taiwan

    Patent acquisition date

    Maych 1,2015

    Patent No
    I474829

  • Patent acquisition country

    Macao

    Patent acquisition date

    June 17, 2015

    Patent No
    J/001685

  • Patent acquisition country

    Mexico

    Patent acquisition date

    June 22, 2015

    Patent No
    330956

  • Patent acquisition country

    Hong Kong

    Patent acquisition date

    July 24,2015

    Patent No
    HK1176876

  • Patent acquisition country

    Indonesia

    Patent acquisition date

    September 30, 2015

    Patent No
    IDP000039589

  • Patent acquisition country

    Russia

    Patent acquisition date

    October 27, 2015

    Patent No
    2567053

  • Patent acquisition country

    Malaysia

    Patent acquisition date

    March 15, 2017

    Patent No
    MY-160509-A

  • Patent acquisition country

    Canada

    Patent acquisition date

    July 11, 2017

    Patent No
    2798556

  • Patent acquisition country

    Republic of India

    Patent acquisition date

    November 13,2019

    Patent No
    324913

Composition having lipolysis-promotive effect Patent overview

  • Patent acquisition country

    Federative Republic of Brazil

    Patent acquisition date

    June 16,2020

    Patent No
    BR112012006872-5

  • Patent acquisition country

    Japan

    Patent acquisition date

    April 16, 2010

    Patent No
    4493725

  • Patent acquisition country

    People’s Republic of China

    Patent acquisition date

    December 17, 2014

    Patent No
    ZL201080043430.1

  • Patent acquisition country

    Macao

    Patent acquisition date

    June 17, 2015

    Patent No
    J/001687

  • Patent acquisition country

    Hong Kong

    Patent acquisition date

    September 18, 2015

    Patent No
    HK1169306

  • Patent acquisition country

    Taiwan

    Patent acquisition date

    November 20, 2015

    Patent No
    I520741

  • Patent acquisition country

    The United States of America

    Patent acquisition date

    July 26, 2016

    Patent No
    US9399043B2

  • Patent acquisition country

    Korea

    Patent acquisition date

    July 19, 2017

    Patent No
    10-1761112

  • Patent acquisition country

    Republic of India

    Patent acquisition date

    March 13,2019

    Patent No
    309156

Research and development of cosmeceuticals.

  • 「Applied the patent for ‘The anti-aging drug for the skin or the gene expression regulation drug’」Patent overview

    We have discovered that the mixture of “special low-molecular weight DNA” and “soybean extracts (F polyamine)” has a synergistic effect in anti-aging of skin and adjusting expression of anti-aging-related genes.

  • 「Anti-aging agent for skin」Cell proliferation action

    We have found that the mixture of special low-molecular weight DNA and soybean extracts (F polyamine) has synergistic effects on activating fibroblasts; that is, effects on cell proliferation promoting action, collagen production promoting action, and hyaluronan production promoting action.

    〈Test using human-derived dermal fibroblast cell line〉
    Test result (1) Cell proliferation action
    Cell proliferation rate increased by 133% by mixing 0.01㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).
    Cell proliferation rate increased by 141% by mixing 0.1㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).


  • 「 Anti-aging agent for skin」Collagen production promoting action

    We have found that the mixture of special low-molecular weight DNA and soybean extracts (F polyamine) has synergistic effects on activating fibroblasts; that is, effects on cell proliferation promoting action, collagen production promoting action, and hyaluronan production promoting action.

    〈Test using human-derived dermal fibroblast cell line〉
    Test result (2) Collagen production promoting action
    Collagen production promoting rate increased by 178% by mixing 0.01㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).
    Collagen production promoting rate increased by 231% by mixing 0.1㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).

  • 「Anti-aging agent for skin」Hyaluronic acid production promoting action

    We have found that the mixture of special low-molecular weight DNA and soybean extracts (F polyamine) has synergistic effects on activating fibroblasts; that is, effects on cell proliferation promoting action, collagen production promoting action, and hyaluronan production promoting action.

    〈Test using human-derived dermal fibroblast cell line〉
    Test result (3) Hyaluronic acid production promoting action
    Hyaluronan production promoting rate increased by 133% by mixing 0.01㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).
    Hyaluronan production promoting rate increased by 140% by mixing 0.1㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).

  • 「Agent for adjusting expression of anti-aging-related genes of skin」Promoting gene expression related to hyaluronan synthesis

    Furthermore, we have also found that the mixture of special low-molecular weight DNA and soybean extracts (F polyamine) facilitates the expression of genes related to hyaluronic acid synthesis, while reducing expression of genes related to hyaluronic acid degradation.

    〈Test using human-derived dermal fibroblast cell line〉
    Test result (1) Expression analysis of hyaluronan synthase-1 (HAS1) genes
    Hyaluronic acid synthesis enzyme-1 genes (HAS1) increased by 1.51±0.26 by mixing 0.1㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).

  • 「Agent for adjusting expression of anti-aging-related genes of skin」Reduced gene expression for hyaluronan degradation

    Furthermore, we have also found that the mixture of special low-molecular weight DNA and soybean extracts (F polyamine) facilitates the expression of genes related to hyaluronic acid synthesis, while reducing expression of genes related to hyaluronic acid degradation.

    〈Test using human-derived dermal fibroblast cell line〉
    Test result (2) Expression analysis of genes of hyaluronan-degrading enzyme (HYAL1)
    Hyaluronan-degrading enzyme - I genes (HYAL1) decreased by 0.58±0.11 by mixing 0.01㎎/ml of special low-molecular weight DNA and 0.27㎎/ml of soybean extracts (F polyamine).

Applied the patent for ‘The anti-aging drug for the skin or the gene expression regulation drug’ Patent overview

  • Patent acquisition country

    Japan

    Patent acquisition date

    July 19,2019

    Patent No
    6555674

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